Cancer is an ecosystem. We map it.
Bioinformatics for cancer research at the intersection of spatial biology, single-cell genomics and cancer genomics. We are the group of Naveed Ishaque, Professor of Cancer Bioinformatics at Charité - Universitätsmedizin Berlin and the BIH Center of Digital Health.
The spatial arrangement of tumour, immune and stromal cells carries information that conventional approaches cannot capture. We work to understand the causal mechanisms that shape cell and tissue structure in development and disease. Our focus is oncology, with active interests in immunology, neurodegeneration and metabolic disease. We build open-source software for the wider field of spatial analysis, including tools that find data-quality problems in spatial transcriptomics.
What we work on
Human disease biology
Cellular ecosystems in cancer and metabolic disease, and the causal mechanisms behind them.
Single-cell and spatial 'omics
Computational frameworks that resolve heterogeneity and map tissue architecture at single-cell resolution.
Clinical image analysis
Multimodal AI linking routine histology to spatial 'omics, including 3D.
Bioinformatics methods
Open-source software, quality-control frameworks and scalable algorithms for multiplexed data.
Translational medicine
Turning in silico discoveries and AI models into clinical products and diagnostics.
Recent publications
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